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烟草中发现杀死癌细胞的新化合物

杂谈 爱分享 6652浏览 0评论

烟草中发现杀死癌细胞的新化合物

香烟燃烧过程中会释放出数以千万计化合物,随便一种都可能让你提前患上癌症,但是澳大利亚研究人员本周发布了一份最新研究结果,他们在某种作物中发现了一种能够杀死癌细胞的新化合物,同时不损害健康细胞。

而他们发现的这种植物正是致癌大富翁:烟草。

禁止吸烟

澳大利亚拉筹伯大学的研究团队在花烟草(学名Nicotiana alata,为茄科烟草属下的一个种)中发现了这种摧毁癌细胞的蛋白质,而花烟草常用于观赏。NaD1蛋白能够帮助植物抵御真菌和细菌的侵蚀,研究人员发现, NaD1蛋白能够狙击癌细胞。

NaD1会用它尖锐的钳子伸入癌细胞外层膜上的大分子内,撕开癌细胞,在癌细胞还没有将癌变传播到其它细胞之前把细胞的内容全部扯出并摧毁。

“这种强大的对抗癌细胞的机制竟然蕴藏在观赏性烟草作物的花朵中,这多少有些讽刺,但是无论是怎么来的,我们都欢迎。”团队的带头研究者Mark Hulett博士说。

NaD1蛋白最牛逼之处在于专门瞄准癌细胞的能力,目前应用的化疗手段存在许多恶性副作用,会严重影响患者的生活,这些药物不但杀死癌细胞,同时杀死健康细胞,是一种杀敌一千,自损八百的疗法。

研究人员已经了解了这种蛋白的工作机理,现在他们正在研究怎样将NaD1蛋白投入实际抗癌药物。目前该种蛋白正在墨尔本一家生物制药公司进行临床前试验,不过Hulett表示,在这种药物进入医院之前,大概还有十年的路要走。

同时,在烟草中发现抗癌成分不代表烟草抗癌,人们还是应该远离烟草。

禁止吸烟

[爱分享 via 煎蛋][图片来自互联网]

原文:

Australian researchers published findings this week on a newly-discovered plant compound that destroys cancer cells, but leaves healthy cells unharmed. They found it in possibly the last place you’d look for a cancer cure: the family of plants that brings us cancer’s number-one culprit, tobacco.

The research team at Australia’s La Trobe University discovered the cancer-blasting protein in the flowers of Nicotiana alata, a relative of cigarette tobacco that’s usually planted as an ornamental (though it’s sometimes smoked in hookah pipes). A protein called NaD1 helps the plant fight off fungi and bacteria—and, it turns out, that same protein is like a sniper for cancerous cells.

On the cellular level, NaD1 works by plunging sharp pincers into fat molecules present in the outer membranes of cancerous cells. This action rips the cells open, spilling their guts and destroying them before they can spread their cancerous mutations to other cells.

“There is some irony in the fact that a powerful defense mechanism against cancer is found in the flower of a species of ornamental tobacco plant, but this is a welcome discovery, whatever the origin,” said Dr. Mark Hulett, lead investigator in the study.

The most promising aspect of NaD1 is how it specifically targets cancerous cells. Many of the most vicious, lifestyle-limiting side effects of current chemotherapy stems from the fact that the drugs tend to kill healthy cells as well as cancerous cells.

Now that the researchers have an idea how the mechanism works, they’re laboring to see how it can be put to use. Preclinical trials are underway at a Melbourne biotech company, though Dr. Hulett predicts it will take a decade before the substance finds its way to hospitals.

In the meantime, stay away from those tobacco products. The good cousin in the family may work out to be very good, but the bad cousin is still undeniably bad.

[爱分享 via Gizmodo]

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原文地址:http://www.ihref.com/read-15515.html

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  1. 在烟草中发现抗癌成分不代表烟草抗癌,人们还是应该远离烟草。
    爱分享2014-04-07 18:30 回复